• Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes 

      Wessel, Øystein; Krasnov, Aleksei; Timmerhaus, Gerrit; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-16)
      Salmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle ...
    • Assessment of benefits and risks of probiotics in baby foods Bifidobacterium lactis Bb12. 

      Halvorsen, Ragnhild; Narvhus, Judith; Lassen, Jørgen Fr; Midtvedt, Tore; Rugtveit, Jarle; Yazdankhah, Siamak Pour; Andersen, Lene Frost; Frølich, Wenche; Frøyland, Livar; Haugen, Margaretha; Høiby, Anne; Kapperud, Georg; Lunestad, Bjørn Tore; Meltzer, Helle Margrete; Nesbakken, Truls; Nygård, Karin Maria; Robertson, Lucy; Olsvik, Ørjan; Paulsen, Jan Erik; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2010-05-14)
      The Norwegian Scientific Committee for Food Safety (VKM) has appointed an ad hoc-group of experts to answer a request from the Norwegian Food Safety Authority regarding benefit and risk assessment of B. lactis Bb12 in baby foods focusing on the age groups 4-6 months, 6-12 months and 1-3 years. This assessment is based on the literature provided by the notifier as well as that found by a MEDLINE search.
    • Chlorhexidine compounds in cosmetic products Risk assessment of antimicrobial and antibiotic resistance development in microorganisms 

      Lunestad, Bjørn Tore; Møretrø, Trond; Hegstad, Kristin; Langsrud, Solveig; Scheie, Anne Aamdal; Kapperud, Georg; Lassen, Jørgen Fr; Nygård, Karin Maria; Robertson, Lucy; Nesbakken, Truls; Olsvik, Ørjan; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2010-04-15)
      Chlorhexidine and its salts are reported as being used in cosmetics as an active ingredient to give the desired effect or as a preservative in concentrations of up to 0.3 %. Such products include mouthwashes, hair dying and bleaching formulations, shampoos, anti hair “aging” products and exfoliants, body lotions, eye creams, face cleansers, sun cream, after-sun lotions, ...
    • Comments on: The opinion of the Agence française de sécurité sanitaire (Afssa) on changes to the control measures for sheep and goat herds in which a case of classical or atypical scrapie has been detected. Opinion of the Panel on Biological Hazards & Panel on Animal Health and Animal Welfare of the Norwegian Scientific Committee for Food Safety 

      Rimstad, Espen; Håvarstein, Leiv Sigve; Kapperud, Georg; Lassen, Jørgen Fredrik; Lunestad, Bjørn Tore; Nesbakken, Truls; Robertson, Lucy Jane; Skjerve, Eystein; Wasteson, Yngvild; Bøe, Knut Egil; Arnemo, Jon Martin; Braastad, Bjarne Olai; Fossum, Kåre; Hjeltnes, Brit Kristine; Håstein, Tore; Juell, Jon-Erik; Valle, Paul Steinar; Waagbø, Rune (Research report; Forskningsrapport, 2007-02)
      The Agence française de sécurité sanitaire (Afssa) was asked by the Direction général de l’alimentation (DGAI) to comment on various proposals made by the CES ESST (expert committee on TSEs) in the EC TSE Roadmap.<p><p> On January 24<sup>rd</sup> 2007, the Norwegian Scientific Committee for Food Safety (Panel on Biological Hazards and Panel on Animal Health and Animal welfare) received a request ...
    • Dekontaminering av pattedyrslakt ved bruk av damp eller varmt vann. Uttalelse fra Faggruppe for hygiene og smittestoffer i Vitenskapskomiteen for mattrygghet 

      Nesbakken, Truls; Christensen, Hardy; Skjerve, Eystein; Nygård, Karin Maria; Yazdankhah, Siamak Pour; Lunestad, Bjørn Tore; Kapperud, Georg; Lassen, Jørgen Fr; Robertson, Lucy; Olsvik, Ørjan; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2010-04-15)
      Mattilsynet har gitt VKM i oppgave å foreta en risikovurdering når det gjelder ”dekontaminering av pattedyrslakt ved bruk av varmt vann eller damp”. Da det er en bestemtdekontamineringsteknologi Mattilsynet ønsker utredet, velger faggruppen å bruke den mer presise betegnelsen ”overflatepasteurisering av slakt” som er i tråd med uttrykk og definisjoner som forskere innenfor dette området har benyttet ...
    • Detection of specific Atlantic salmon antibodies against salmonid alphavirus using a bead-based immunoassay 

      Teige, Lena Hammerlund; Aksnes, Ida; Røsæg, Magnus Vikan; Jensen, Ingvill; Jørgensen, Jorunn; Sindre, Hilde; Collins, Catherine; Collet, Bertrand; Rimstad, Espen; Dahle, Maria; Boysen, Preben (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)
      Salmonid alphavirus (SAV) is the etiological cause of pancreas disease (PD) in Atlantic salmon (<i>Salmo salar</i>). Several vaccines against SAV are in use, but PD still cause significant mortality and concern in European aquaculture, raising the need for optimal tools to monitor SAV immunity. To monitor and control the distribution of PD in Norway, all salmonid farms are regularly screened for SAV ...
    • Dissemination of Piscine orthoreovirus-1 (PRV-1) in Atlantic Salmon (Salmo salar) during the Early and Regenerating Phases of Infection 

      Dhamotharan, Kannimuthu; Bjørgen, Håvard; Malik, Muhammad Salman; Nyman, Ingvild Berg; Markussen, Turhan Ali Dadasbilge; Dahle, Maria; Koppang, Erling Olaf; Wessel, Øystein; Rimstad, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-20)
      <i>Piscine orthoreovirus-1</i> (PRV-1) can cause heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (<i>Salmo salar</i>), but the line of events from infection, pathologic change, and regeneration has not been thoroughly described. In this study, the cellular localization and variation of PRV-1 RNA and protein levels were analyzed at different times post-exposure in experimentally ...
    • Evaluation of three commercial bovine ELISA kits for detection of antibodies against Alphaherpesviruses in reindeer (Rangifer tarandus tarandus) 

      Das Neves, Carlos G.; Yoccoz, Nigel G.; Roger, Matthieu; Rimstad, Espen; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-03-09)
      Background: The genus <i>Varicellovirus</i> (family <i>Herpesviridae</i> subfamily <i>Alphaherpesvirinae</i>) includes a group of viruses genetically and antigenically related to bovine herpesvirus 1 (BoHV-1) among which cervid herpesvirus 2 (CvHV-2) can be of importance in reindeer. These viruses are known to be responsible for different diseases in both wild and domestic animals. Reindeer are ...
    • Oppdatert risikovurdering – introduksjon av høypatogent aviært influensavirus til Norge våren 2007 

      Alexander, Jan; Farstad, Wenche Kristin; Haugen, Margaretha; Krogdahl, Åshild; Lie, Øyvind; Næss, Bjørn; Sundheim, Leif; Rimstad, Espen; Dybing, Erik; Nes, Ingolf; Skåre, Janneche Utne; Haldorsen, Anne-Kathrine Lundeby; Narvhus, Judith; Kapperud, Georg; Andersen, Lene Frost; Folgerø, Beate Furuto (Research report; Forskningsrapport, 2007-02-15)
      VKM ga i 2006 to risikovurderinger vedrørende introduksjon av høypatogent aviært influensavirus til Norge. Den foreliggende vurderingen er en oppdatering av disse vurderingene og besvarer spørsmål om risiko i ulike situasjoner i Norge våren 2007.
    • Piscine Orthoreovirus (PRV)-3, but Not PRV-2, Cross-Protects against PRV-1 and Heart and Skeletal Muscle Inflammation in Atlantic Salmon 

      Malik, Muhammad Salman; Teige, Lena Hammerlund; Braaen, Stine; Olsen, Anne Berit; Nordberg, Monica; Amundsen, Marit; Kannimuthu, Dhamotharan; Svenning, Steingrim; Edholm, Eva-Stina Isabella; Takano, Tomokazu; Jørgensen, Jorunn; Wessel, Øystein; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-06)
      Heart and skeletal muscle inflammation (HSMI), caused by infection with Piscine orthoreovirus-1 (PRV-1), is a common disease in farmed Atlantic salmon (Salmo salar). Both an inactivated whole virus vaccine and a DNA vaccine have previously been tested experimentally against HSMI and demonstrated to give partial but not full protection. To understand the mechanisms involved in protection against HSMI ...
    • Risikovurdering; import og spredning av tarmpatogene bakterier med krydder og urter 

      Rimstad, Espen; Høiby, E. Arne; Kapperud, Georg; Lassen, Jørgen Fredrik; Lunestad, Bjørn Tore; Nygård, Karin Maria; Olsvik, Ørjan; Nesbakken, Truls; Robertson, Lucy; Tryland, Morten; Tranulis, Michael A.; Vainio, Kirsti; Blom, Hans (Research report; Forskningsrapport, 2007-09-26)
      Forbruket av krydder i Norge øker og ligger per i dag på vel ½ kg per person og år (2006). Forbruket hos oss er imidlertid fortsatt langt lavere enn i enkelte andre industriland (eksempelvis USA med et forbruk på 1,6 kilo per person og år) og vil derfor sannsynligvis fortsatt øke ganske betydelig. Også antall ulike kryddertyper øker, parallelt med økende interesse for ”eksotisk” (ikke minst asiatisk) ...
    • Risk assessment of import and dissemination of intestinal pathogenic bacteria via fresh herbs and leafy vegetables from South-East Asia. Opinion of the Panel on Biological Hazards 

      Lassen, Jørgen Fredrik; Johannessen, Gro Skøien; Høiby, Ernst Arne; Kapperud, Georg; Lunestad, Bjørn Tore; Nesbakken, Truls; Nygård, Karin Maria; Olsvik, Ørjan; Robertson, Lucy Jane; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2008-06)
      Several studies have demonstrated that fresh herbs and green or leafy vegetables can be contaminated by intestinal pathogenic bacteria such as <i>Salmonella</i> spp. Although systematic surveys are probably not conducted in any countries some places, in recent years the Rapid Alert System for Food and Feed (RASFF) has received approximately 30 alerts annually on the detection of potentially pathogenic ...
    • Risk assessment of marking and tracing methods with regards to the welfare of farmed salmonids. Opinion of the Panel on Animal Health and Welfare of the Norwegian Scientific Committee for Food Safety 

      Mortensen, Stein; Kristiansen, Tore S; Mejdell, Cecilie Marie; Uglem, Ingebrigt; Agdestein, Angelika; Basic, Dean; Bergh, Øivind; Brun, Edgar; Bøe, Knut Egil; Das Neves, Carlos G; Godfroid, Jacques; Gudding, Roar; Hoel, Kristian; Rimstad, Espen; Hjeltnes, Brit (Research report; Forskningsrapport, 2016-12-15)
    • Risk assessment on import of Australian redclaw crayfish to Norway. Opinion of the Panel on Animal Health and Welfare of the Norwegian Scientific Committee for Food Safety 

      Bergh, Øivind; Das Neves, Carlos G; Hindar, Kjetil; Høgåsen, Helga Rachel; Jelmert, Anders; Vrålstad, Trude; Agdestein, Angelika; Asmyhr, Maria Gulbrandsen; Basic, Dean; Brun, Edgar; Bøe, Knut Egil; Godfroid, Jacques; Gudding, Roar; Hoel, Kristian; Mejdell, Cecilie Marie; Mortensen, Stein; Rimstad, Espen; Hjeltnes, Brit (Research report; Forskningsrapport, 2016-11-30)
      <i>Main message</i>: It seems unlikely that the Australian red claw clayfish will establish reproductive populations under Norwegian climate conditions, but hitchhiker organisms and infectious agents could potentially follow the import, and unless managed, may pose risks to biodiversity and aquatic animal health. This is the conclusion in a risk assessment from the Norwegian Scientific Committee for ...
    • Risk assessment on the use of triclosan in cosmetics; Development of antimicrobial resistance in bacteria - II. Opinion of the Panel on Biological Hazards Norwegian Scientific Committee for Food Safety 

      Kapperud, Georg; Høiby, Ernst Arne; Lassen, Jørgen Fredrik; Lunestad, Bjørn Tore; Nesbakken, Truls; Nygård, Karin Maria; Olsvik, Ørjan; Rimstad, Espen; Robertson, Lucy Jane; Tranulis, Michael A.; Tryland, Morten (Research report; Forskningsrapport, 2007-02)
      Den Europa kommisjonens vitenskapskomité for forbruksvarer (SCCP) konkluderte 10. oktober 2006 med at det på grunnlag av tilgjengelige data ikke er funnet bevis for at triklosan i kosmetiske produkter kan føre til resistens – eller kryssresistensutvikling hos bakterier. Til tross for at en slik sammenheng kan være sannsynlig, finnes det ikke god dokumentasjon.<p><p> Siden denne konklusjonen ikke ...
    • Risk assessment on use of Lactobacillus rhamnosus (LGG) as an ingredient in infant formula and baby foods (II) 

      Rimstad, Espen; Andersen, Lene Frost; Frølich, Wenche; Frøyland, Livar; Halvorsen, Ragnhild; Høiby, Ernst Arne; Kapperud, Georg; Lunestad, Bjørn Tore; Lassen, Jørgen Fredrik; Meltzer, Helle Margrete; Narvhus, Judith Ann; Nygård, Karin; Nesbakken, Truls; Olsvik, Ørjan; Paulsen, Jan Erik; Robertson, Lucy Jane; Tranulis, Michael A.; Tryland, Morten; Vainio, Kirsti; Haugen, Margaretha (Research report; Forskningsrapport, 2007-06-15)
      On 10. March 2006 , The Norwegian Food Safety Authority (Mattilsynet) decided that, on the basis of VKM’s previous risk assessment (2005), Nutramigen 1 with Lactobacillus rhamnosus GG (LGG) could not be marketed in Norway as medical foods for infants (0-4 months). In addition, The Norwegian Food Safety Authority (Mattilsynet) decided (08. November ...
    • Risk assessment on welfare in turkeys. Opinion of the Panel of Animal Health and Welfare of the Norwegian Scientific Committee for Food Safety 

      Hoel, Kristian; Agdestein, Angelika; Bøe, Knut Egil; Hansen, Magne; Janczak, Andrew M.; Bergh, Øivind; Brun, Edgar; Das Neves, Carlos G; Godfroid, Jacques; Gudding, Roar; Mejdell, Cecilie Marie; Mortensen, Stein; Rimstad, Espen; Hjeltnes, Brit (Research report, 2016-02-15)
      The Norwegian Food Safety Authority (NFSA) asked the Norwegian Scientific Committee for Food Safety (Vitenskapskomiteen for mattrygghet, VKM) for a risk assessment on turkey welfare. The VKM report will be used by NFSA in assessing the need for amending the existing regulations, competence requirements, and guidelines for surveillance and control related to keeping turkeys. Inspectors from NFSA ...
    • Salmonella diarizonae hos dyr i Norge. Konsekvenser for dyr og mennesker. 

      Nesbakken, Truls; Lassen, Jørgen Fr; Nygård, Karin Maria; Østerås, Olav; Høiby, Ernst Arne; Kapperud, Georg; Lunestad, Bjørn Tore; Olsvik, Ørjan; Robertson, Lucy; Tranulis, Michael A.; Tryland, Morten; Rimstad, Espen (Research report; Forskningsrapport, 2008-09-09)
      S. diarizonae er et subspecies av Salmonella som påvises endemisk hos sau i enkelte regioner i Norge. Det er derfor stilt spørsmål om mikrobens potensielle og reelle betydning for både folke- og dyrehelsen. Det er også stilt spørsmål ved påstanden om at Norge har en tilnærmet salmonella-fri husdyrpopulasjon kan forsvares når S. diarizonae påvises relativt ofte hos sau i Norge i dag. Mattilsynet har ...
    • Sequence Analysis of the Genome of Piscine Orthoreovirus (PRV) Associated with Heart and Skeletal Muscle Inflammation (HSMI) in Atlantic Salmon (Salmo salar) 

      Markussen, Turhan; Dahle, Maria Krudtaa; Tengs, Torstein; Løvoll, Marie Therese; Finstad, Øystein Wessel; Wiik-Nielsen, Christer R.; Grove, Søren; Lauksund, Reidunn Silje; Robertsen, Børre; Rimstad, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Piscine orthoreovirus (PRV) is associated with heart- and skeletal muscle inflammation (HSMI) of farmed Atlantic salmon (Salmo salar). We have performed detailed sequence analysis of the PRV genome with focus on putative encoded proteins, compared with prototype strains from mammalian (MRV T3D)- and avian orthoreoviruses (ARV-138), and aquareovirus (GCRV-873). Amino acid identities were low for ...
    • Sequence Analysis of the Genome of Piscine Orthoreovirus (PRV) Associated with Heart and Skeletal Muscle Inflammation (HSMI) in Atlantic Salmon (Salmo salar) 

      Markussen, Turhan; Dahle, Maria Krudtaa; Tengs, Torstein; Løvoll, Marie Therese; Finstad, Øystein Wessel; Wiik-Nielsen, Christer R.; Grove, Søren; Lauksund, Reidunn Silje; Robertsen, Børre; Rimstad, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Piscine orthoreovirus (PRV) is associated with heart- and skeletal muscle inflammation (HSMI) of farmed Atlantic salmon (Salmo salar). We have performed detailed sequence analysis of the PRV genome with focus on putative encoded proteins, compared with prototype strains from mammalian (MRV T3D)- and avian orthoreoviruses (ARV-138), and aquareovirus (GCRV-873). Amino acid identities were low for ...